Diclofenac induces basophil degranulation without increasing CD63 expression in sensitive patients
نویسندگان
چکیده
منابع مشابه
In vitro basophil activation using CD63 expression in patients with bee and wasp venom allergy.
The diagnosis of insect venom allergy and the indication for specific immunotherapy is based on history, skin tests and demonstration of hymenoptera venom-specific IgE-antibodies. Cellular tests can add useful information but the role of basophil activation tests for the different venoms has to be elucidated further. We evaluated positive reactions in a basophil activation test using CD63 expre...
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Polymorphonuclear neutrophils (PMNs) play an important role in chronic obstructive pulmonary disease (COPD) pathogenesis. The tetraspanin CD63 is a membrane marker of azurophilic granules and is actively involved in the process of PMN endocytosis and azurophilic granule exocytosis. In this study, we investigated genetic polymorphisms of the CD63 gene, quantified CD63 expression and PMN myeloper...
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متن کاملHuman basophil degranulation test in diagnosis of hydatidosis.
Protein and energy malnutrition and iron-deficiency anaemia are widespread among preschool children in India. Because of a poor antibody response in severely malnourished children admitted to hospital it has been suggested that mass vaccination programmes would not be effective in populations where malnutrition is widespread. Earlier studies by this institute, however, have shown that most chil...
متن کاملUse of CD63 expression as marker of in vitro basophil activation in identifying the culprit in insect venom allergy.
BACKGROUND The diagnosis of insect venom allergy and the indication for specific immunotherapy is based on history, skin tests and demonstration of hymenoptera venom specific IgE-antibodies. In cases with contradictory test results additional cellular tests are recommended. OBJECTIVE We evaluated the usefulness of a newly introduced test based on basophil CD63 expression as marker of activati...
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ژورنال
عنوان ژورنال: Clinical and Experimental Immunology
سال: 2006
ISSN: 0009-9104,1365-2249
DOI: 10.1111/j.1365-2249.2006.03265.x